The Union Square Boutique Hotel in San Francisco offers the perfect location and a warm, inviting welcome for your visit to the City by the Bay. The Villa Florence Hotel evokes San Francisco's Italian heritage through its luxury hotel decor, family-style hospitality and Italian spirit. Located on the Powell Street Cable Car line, just steps from downtown San Francisco and Moscone Convention Center, the spacious guestrooms and first class service will inspire you to return again and again. Featuring Italian-style romantic hotel rooms, The Villa Florence Hotel is a celebration of Italy right on Union Square. Guests are assured a true San Francisco experience, by capturing the Italian spirit that is such an intrinsic part of the City. Recreation. Concierge. Complimentary Business Center. Complimentary fitness center. In-room spa services